Modelos animales de cáncer y otras enfermedades
Publicaciones
Modelos animales de cáncer y otras enfermedades
- In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution. Cell Genomics. 2023
- PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Nature Communications. 2019
- Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature. 2018
- Disentangling PTEN-cooperating tumor suppressor gene networks in cancer. Molecular & cellular oncology. 2017
- A single-copy Sleeping Beauty transposon mutagénesis screen identifies new PTEN-cooperating tumor suppressor genes. Nature Genetics. 2017
- Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. Nature Protocols. 2017
- CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. PNAS. 2015
- A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics. 2014
- Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. Nature Communications. 2013
- A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell. 2013
- Splicing-directed therapy in a new mouse model of human accelerated aging. Science Translational Medicine. 2011
- Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO Journal. 2011
- Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011
- Autophagy is essential for mouse sense of balance. Journal of Clinical Investigation. 2010
- PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice. Science. 2010